Basic principles and key aspects of molecular design, synthesis, structure and reactivity of carbon based molecules, organo-transition metal chemistry and metal complexes with examples taken from important biological, industrial and environmental processes. It will cover aspects of reactive intermediates; carbocations; molecular rearrangements; nucleophilic substitution; elimination reactions; free radicals; aromatic and heterocyclic chemistry; pericyclic reactions; carbonyl compounds; key principles of coordination chemistry including geometry, properties, bonding and stability in transition metal complexes; metal coordination environments in nature; principles of organometallic chemistry and catalysis.